Canadian Health Policy
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چکیده
Anti-VEGF Drugs Anti-VEGF drugs are used to treat retinal conditions such as the wet form of age-related macular degeneration (wAMD) which is responsible for 80-90% of the vision loss associated with AMD. Avastin, Lucentis and Eylea are anti-VEGF drugs. Avastin was developed as a systemic treatment for cancer. It was also considered for retinal conditions, but evidence showed that systemic exposure to Avastin increases the risk of thromboembolic events. Using knowledge gained from Avastin, decades of innovative research led to the development of Lucentis and Eylea, which are administered by intravitreal injection into the eye. Lucentis and Eylea are approved by Health Canada for retinal conditions, whereas Avastin is not. Avastin has a serious warning in its product monograph (or ‘label’) that it is ‘not formulated and has not been authorized for intravitreal use’. Nevertheless, Avastin is prescribed off-label by clinicians to treat retinal conditions because it is less expensive than the other drugs.
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